Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 1281
interventional 1168
Observational 101
Registry 12

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 551
Biological 71
Drug|Other 64
Biological|Drug 50
Drug|Procedure 49
Biological|Drug|Procedure|Radiation 43
Drug|Procedure|Radiation 36
Biological|Drug|Procedure 35
Procedure 30
Drug|placebo 25
Drug|Other|Procedure|Radiation 23
Other 21
Biological|Drug|Other 17
Biological|Drug|Other|Procedure|Radiation 17
Drug|Radiation 12
Biological|Drug|Radiation 11
Device 10
Biological|Other 8
Drug|Other|Procedure 8
Biological|Drug|Other|Procedure 6
Biological|Procedure 6
Other|Procedure 6
Device|Drug 5
Device|Drug|Procedure 5
Dietary Supplement 4
Drug|Genetic|Other 4
Biological|Drug|Genetic|Other|Procedure 3
Biological|Drug|placebo 3
Biological|placebo 3
Dietary Supplement|Drug 3
Dietary Supplement|placebo 3
Drug|Genetic|Other|Procedure 3
Behavioral 2
Biological|Device|Drug 2
Biological|Other|placebo 2
Combination Product 2
Genetic 2
Behavioral|Dietary Supplement|Other|Procedure 1
Behavioral|Drug 1
Behavioral|Other 1
Biological|Combination Product|Drug 1
Biological|Device|Drug|Other 1
Biological|Device|Drug|Procedure|Radiation 1
Biological|Device|Drug|Radiation 1
Biological|Dietary Supplement|Drug|Procedure 1
Biological|Drug|placebo|Procedure 1
Biological|Genetic|Other 1
Biological|Genetic|Other|Procedure 1
Biological|Other|Procedure 1
Device|Drug|Other|Procedure|Radiation 1
Device|Other 1
Diagnostic Test 1
Drug|Genetic|Other|Procedure|Radiation 1
Drug|Genetic|Procedure|Radiation 1
Drug|Other|placebo 1
Drug|Other|placebo|Procedure 1
Drug|Other|Radiation 1
Drug|placebo|Procedure 1
Genetic|Radiation 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 838
France 29
NA 23
United Kingdom 18
Japan 15
United States|Canada 15
China 14
Germany 14
Korea, Republic of 9
Italy 8
United States|France 8
Canada 7
Australia 5
Israel 5
Spain 5
Singapore 4
United States|Australia|Canada 4
United States|Germany 4
United States|Italy 4
Belgium 3
Denmark 3
Netherlands 3
Russian Federation 3
United States|Belgium 3
United States|Germany|Italy 3
United States|Germany|Netherlands 3
United States|United Kingdom 3
Belgium|Netherlands 2
Brazil 2
France|Monaco 2
Switzerland 2
Taiwan 2
United States|Denmark 2
United States|Denmark|Germany 2
Algeria|Argentina|Canada|China|Germany|Italy|Korea, Republic of|Spain|Sweden|United Kingdom 1
Australia|Bulgaria|France|Germany|Greece|Hungary|Italy|Netherlands|Poland|Spain|United Kingdom 1
Australia|Czechia|France|Israel|Japan|Spain 1
Australia|France 1
Austria|Belgium|Czechia|France|Germany|Greece|Italy|Spain|Switzerland 1
Austria|Czechia|Germany|Italy|Poland|United Kingdom 1
Austria|Finland|Germany|Russian Federation 1
Belgium|Canada|Croatia|Germany|Portugal|United Kingdom 1
Belgium|Canada|Czech Republic|Finland|France|Germany|United States|Greece|Israel|Slovakia|Switzerland|Turkey|United Kingdom 1
Belgium|Canada|Germany|United Kingdom 1
Belgium|Czech Republic|France|Germany|Italy|Netherlands 1
Belgium|Czechia|France|Germany|Netherlands|Slovakia 1
Belgium|France|Germany|Israel|Italy|Netherlands|Spain|Sweden|United Kingdom 1
Belgium|France|Portugal 1
Belgium|Germany|Netherlands|Switzerland 1
Belgium|Germany|United Kingdom 1
Bulgaria|France|Germany|Greece|Russian Federation 1
Canada|United States|Australia|Netherlands|New Zealand|Puerto Rico|Switzerland 1
Denmark|Norway|Sweden 1
Denmark|United Kingdom 1
Finland 1
Finland|France|Germany|Hungary|Italy|Poland 1
France|Austria|Belgium|Czechia|Denmark|Germany|Ireland|Italy|Netherlands|Spain|Sweden|Switzerland|United Kingdom 1
France|Germany 1
France|Germany|Italy|Slovenia 1
France|Germany|Netherlands 1
France|Italy 1
France|Switzerland 1
France|Tunisia 1
Germany|Italy|Spain 1
Germany|Netherlands 1
Germany|Netherlands|United Kingdom 1
Germany|Switzerland 1
Germany|United States|Belgium|Canada|France|Italy|Netherlands|Spain|Sweden|Turkey|United Kingdom 1
Hong Kong 1
Hungary 1
Italy|Saudi Arabia|United Kingdom 1
Italy|United Kingdom 1
Japan|Korea, Republic of 1
Japan|Korea, Republic of|Taiwan 1
Spain|United States|Australia|Bulgaria|Czechia|France|Germany|Greece|Hungary|Italy|Netherlands|Poland|Russian Federation|Sweden|United Kingdom 1
Sweden 1
Sweden|United States|Belgium|Canada|Czechia|Denmark|France|Germany|Italy|Japan|Korea, Republic of|Poland|Spain|United Kingdom 1
Thailand 1
United States|Argentina|Belgium|Brazil|Canada|Czechia|Germany|Greece|Hong Kong|Hungary|Ireland|Israel|Italy|Korea, Republic of|Mexico|Netherlands|Poland|Puerto Rico|Russian Federation|Spain|Taiwan|Thailand 1
United States|Australia 1
United States|Australia|Austria|Belgium|Canada|Croatia|Czechia|Estonia|France|Germany|Hungary|India|Ireland|Israel|Italy|Japan|Poland|Russian Federation|Spain|Sweden|Switzerland|United Kingdom 1
United States|Australia|Austria|Belgium|Canada|Czechia|France|Germany|Israel|Italy|Japan|Lithuania|Netherlands|Poland|Portugal|Russian Federation|Spain|Sweden|Switzerland|Taiwan|Turkey|Ukraine|United Kingdom 1
United States|Australia|Austria|Belgium|Canada|Czechia|France|Germany|Israel|Italy|Japan|Poland|Portugal|Spain|Turkey|United Kingdom 1
United States|Australia|Austria|Brazil|Canada|China|Czechia|France|Germany|Israel|Italy|Spain|Japan|Korea, Republic of|Mexico|Netherlands|Poland|Russian Federation|Taiwan|United Kingdom 1
United States|Australia|Belgium|Brazil|Canada|China|Czechia|France|Germany|Greece|Israel|Italy|Japan|Korea, Republic of|Mexico|Poland|Russian Federation|Spain|Turkey|United Kingdom 1
United States|Australia|Belgium|Brazil|Canada|Czechia|Denmark|Finland|France|Germany|Greece|Israel|Italy|Korea, Republic of|Mexico|Netherlands|Norway|Poland|Portugal|Spain|Sweden|Turkey|United Kingdom 1
United States|Australia|Belgium|Bulgaria|Canada|France|Germany|Greece|Israel|Italy|Lebanon|Malaysia|Netherlands|Spain|Sweden|Taiwan|Thailand|Tunisia|Turkey|United Kingdom 1
United States|Australia|Belgium|Czech Republic|Denmark|France|Germany|Greece|Italy|Netherlands|Russian Federation|Spain|Sweden|Switzerland|United Kingdom 1
United States|Australia|Belgium|France|Germany|Italy|Poland|Spain|United Kingdom 1
United States|Australia|Belgium|Germany|Israel|Italy|Korea, Republic of|Russian Federation|Spain|United Kingdom 1
United States|Australia|Bulgaria|Canada|China|Denmark|Greece|Hong Kong|Italy|Malaysia|Mexico|New Zealand|Romania|Russian Federation|Switzerland|Thailand|United Kingdom 1
United States|Australia|Canada|France|Germany|Italy|Korea, Republic of|Spain|United Kingdom 1
United States|Australia|Canada|France|Germany|Italy|United Kingdom 1
United States|Australia|Canada|New Zealand|Puerto Rico|Saudi Arabia 1
United States|Australia|Canada|New Zealand|Saudi Arabia 1
United States|Australia|Canada|Puerto Rico 1
United States|Australia|Denmark|France|Germany|Italy|Spain|Sweden 1
United States|Australia|Finland|France|Germany|Netherlands|Spain|United Kingdom 1
United States|Australia|Finland|Italy|Singapore|Spain|Switzerland 1
United States|Australia|France|Germany|Italy|Japan|Netherlands 1
United States|Australia|France|Spain 1
United States|Australia|Germany 1
United States|Austria|Belgium|Canada|Czechia|France|Germany|Greece|Hong Kong|Hungary|Italy|Japan|Korea, Republic of|Norway|Spain|Sweden|Taiwan|Turkey|United Kingdom 1
United States|Austria|Belgium|Canada|France|Germany|Hungary|Italy|Korea, Republic of|Spain|Sweden|Switzerland|Thailand|United Kingdom 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Netherlands|Poland|Portugal|Spain|United Kingdom 1
United States|Belgium|Bulgaria|Canada|Czechia|France|Germany|Ireland|Israel|Italy|Netherlands|Spain 1
United States|Belgium|Canada|Croatia|France|Germany|Israel|Italy|Netherlands|Portugal|Spain|Sweden|United Kingdom 1
United States|Belgium|Canada|Czechia|France|Germany|Israel|Italy|Korea, Republic of|Netherlands|Russian Federation|Spain|United Kingdom 1
United States|Belgium|Canada|France|Germany|United Kingdom 1
United States|Belgium|France|Germany|Italy|Spain 1
United States|Belgium|Italy|Netherlands|Russian Federation|Spain 1
United States|Brazil 1
United States|Brazil|Denmark|France|Germany|Hong Kong|Italy|Korea, Republic of|Puerto Rico|Taiwan|United Kingdom 1
United States|Brazil|France|Israel|Italy|Netherlands|Portugal|Singapore|Spain|United Kingdom 1
United States|Canada|France|Italy|Norway|Spain|United Kingdom 1
United States|Canada|France|Spain 1
United States|Canada|Germany|Israel|Spain 1
United States|Canada|Germany|Italy|Poland|Spain 1
United States|Canada|New Zealand 1
United States|Canada|Puerto Rico 1
United States|France|Germany 1
United States|France|Germany|Spain 1
United States|France|Germany|United Kingdom 1
United States|France|United Kingdom 1
United States|Georgia 1
United States|Germany|Spain 1
United States|Hungary|Israel|Italy|Spain 1
United States|India|Israel 1
United States|Israel 1
United States|Israel|Peru 1
United States|Italy|Netherlands|Singapore|Spain 1
United States|Korea, Republic of 1
United States|Singapore 1
United States|Spain 1
United States|Switzerland 1

Sites per Study

Site_count Study_Count
1 687
2 83
3 50
4 32
5 36
6 30
7 15
8 21
9 13
10 12
11 19
12 8
13 7
14 7
15 8
16 6
17 8
18 2
19 4
20 3
21 8
22 4
23 4
24 9
25 2
26 2
27 1
28 8
29 1
30 2
31 3
32 2
33 1
34 2
35 2
36 2
37 3
38 6
39 2
40 1
42 1
43 1
48 3
52 1
53 1
54 1
59 3
61 1
65 2
66 1
68 1
71 1
72 1
74 1
76 1
81 1
85 3
87 2
88 2
92 1
94 2
96 2
99 1
108 1
119 1
120 1
123 1
158 1
165 1
180 1
185 1
196 1
201 1
234 1
237 1
242 1
269 1
298 1
326 1
341 1
513 1

Phase

Phase Study_Count
Phase 2 483
Phase 1 315
Phase 1/Phase 2 167
Phase 3 97
N/A 70
Phase 4 16
Phase 2/Phase 3 12
Early Phase 1 8

Number of Arms

Number_of_Arms Count_of_Studies
1 606
2 246
3 61
4 30
5 18
6 12
7 5
8 1
9 2
10 1
11 1
16 1
NA 184

Number of Updates

Count of Versions Count of Studies
1 19
2 41
3 45
4 56
5 49
6 45
7 49
8 48
9 39
10 51
11 39
12 46
13 58
14 50
15 41
16 26
17 23
18 47
19 33
20 21
21 23
22 18
23 15
24 16
25 20
26 23
27 17
28 19
29 8
30 12
31 5
32 6
33 5
34 6
35 10
36 10
37 6
38 6
39 2
40 6
41 5
42 6
43 1
44 3
45 3
46 4
47 3
48 2
49 3
50 4
51 6
52 3
53 1
54 1
55 4
59 1
61 1
62 2
64 1
65 3
67 2
68 1
69 1
70 2
71 3
72 2
77 1
78 1
81 3
82 1
83 2
84 2
89 1
92 1
93 2
94 1
98 2
101 1
103 1
106 1
110 1
112 2
127 1
129 2
130 1
133 1
136 1
139 1
141 1
162 1
165 1
174 1
192 1
206 1
213 1
232 1
320 1
439 1
1047 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 23488 1149 20.442124
Contacts/Locations 8503 1062 8.006591
Arms 2798 857 3.264877
Interventions 2798 857 3.264877
Eligibility 2526 863 2.926999
Study Description 2500 753 3.320053
Conditions 2270 613 3.703099
Study Design 2254 903 2.496124
Recruitment Status 2243 1046 2.144360
Study Identification 2094 784 2.670918
Outcome Measures 1842 756 2.436508
Sponsor/Collaborators 1501 742 2.022911
None (earliest Version on record) 1168 1168 1.000000
Oversight 1053 706 1.491501
References 597 295 2.023729
More Information 538 169 3.183432
Results 257 257 1.000000
IPDSharing 127 104 1.221154
Baseline Characteristics 116 81 1.432099
Reported Adverse Events 67 55 1.218182
Results Submission Events 64 64 1.000000
Documents 60 58 1.034483
Participant Flow 54 46 1.173913

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 6.000 2.0000 1.00000 2.00000 3.0000 19.0000 6.0000 21.000
1st Qu. 18.750 21.0000 19.00000 30.00000 30.0000 125.5000 124.0000 44.750
Median 20.500 40.0000 30.00000 45.00000 50.0000 175.0000 224.0000 71.000
Mean 20.375 107.8788 41.53608 65.45625 84.4207 460.9091 337.6703 92.625
3rd Qu. 25.250 80.0000 48.00000 68.25000 100.0000 303.5000 386.0000 114.250
Max. 30.000 1732.0000 302.00000 500.00000 3621.0000 2000.0000 2000.0000 309.000

Trial Group Type

group_type Group_Count
Experimental 1397
NA 184
Active Comparator 130
Other 69
Placebo Comparator 39
No Intervention 25
Sham Comparator 1

Intervention Model

intervention_model Study_Count
Single Group Assignment 707
Parallel Assignment 288
NA 122
Sequential Assignment 36
Crossover Assignment 11
Factorial Assignment 4

Primary Purpose

primary_purpose Study_Count
Treatment 1037
Supportive Care 70
Prevention 29
NA 10
Other 6
Basic Science 5
Health Services Research 5
Diagnostic 3
Screening 3

Observational Studies

Studies by Country

Country Study_Count
United States 46
France 9
Spain 6
Italy 5
NA 5
Germany 4
Korea, Republic of 4
China 2
Japan 2
United States|Australia|Canada 2
Austria 1
Austria|Belgium|Czech Republic|Denmark|Germany|Ireland|Italy|Netherlands|Spain|Switzerland 1
Austria|Croatia 1
Austria|Croatia|Czechia|Denmark|France|Germany|Greece|Israel|Italy|Netherlands|Poland|Portugal|Romania|Serbia|Spain|Sweden|Switzerland|United Kingdom 1
Austria|Germany 1
Denmark 1
Egypt 1
France|Germany|Italy|Spain 1
Mexico 1
Taiwan 1
United States|Austria|Belgium|Brazil|China|Croatia|Czechia|France|Germany|Italy|Taiwan|United Kingdom 1
United States|Belgium|Canada|Germany|Netherlands|United Kingdom 1
United States|Canada 1
United States|Germany 1
United States|Israel 1
United States|Puerto Rico 1

Sites per Study

Site_count Study_Count
1 52
2 10
3 3
4 1
5 1
6 3
7 2
8 1
9 1
10 1
12 2
13 1
15 2
16 1
18 1
19 1
20 1
22 1
23 1
25 1
43 1
45 1
48 1
50 1
53 1
66 1
70 1
96 1
137 1
142 1
225 1
234 1
280 1
292 1

Number of Updates

Count of Versions Count of Studies
1 6
2 6
3 9
4 9
5 12
6 6
7 5
8 4
9 9
10 6
11 4
12 2
13 1
15 2
16 2
17 1
18 1
19 1
20 2
24 2
25 1
34 1
37 1
38 1
41 1
84 1
122 1
253 1
267 1
285 1
391 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 2143 95 22.557895
Contacts/Locations 1507 84 17.940476
Study Design 169 77 2.194805
Recruitment Status 139 82 1.695122
Conditions 119 43 2.767442
Study Description 106 46 2.304348
Eligibility 102 54 1.888889
None (earliest Version on record) 101 101 1.000000
Study Identification 101 56 1.803571
Sponsor/Collaborators 94 61 1.540984
Groups 81 40 2.025000
Interventions 81 40 2.025000
Outcome Measures 80 46 1.739130
Oversight 43 37 1.162162
References 32 17 1.882353
IPDSharing 6 5 1.200000
More Information 4 1 4.000000
Baseline Characteristics 3 1 3.000000
Results 3 3 1.000000
Results Submission Events 3 3 1.000000
Documents 2 2 1.000000
Participant Flow 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 8.00
1st Qu 64.50
Median 151.50
Mean 810.99
3rd Qu 464.00
Max 15000.00

Observation Model

observational_model Study_Count
Cohort 47
Case-Only 25
NA 10
Case-Control 9
Other 8
Case Control 2

Time Perspective

time_perspective Study_Count
Prospective 76
NA 9
Retrospective 7
Cross-Sectional 6
Other 3

Registries

Studies by Country

Country Study_Count
United States 5
Austria 1
Belgium 1
Belgium|Denmark|France|Germany|Greece|Italy|Luxembourg|Norway|Spain|Sweden|United Kingdom 1
France 1
Germany 1
Hong Kong 1
Korea, Republic of 1

Sites per Study

Site_count Study_Count
1 8
2 1
7 1
21 1
135 1

Number of Updates

Count of Versions Count of Studies
1 1
2 3
3 3
6 2
7 1
11 1
13 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 47 11 4.272727
Contacts/Locations 24 7 3.428571
None (earliest Version on record) 12 12 1.000000
Recruitment Status 9 6 1.500000
Eligibility 8 6 1.333333
Study Design 8 5 1.600000
Study Identification 7 3 2.333333
Oversight 6 6 1.000000
Sponsor/Collaborators 4 3 1.333333
Outcome Measures 3 3 1.000000
Study Description 3 2 1.500000
Conditions 2 2 1.000000
Groups 2 2 1.000000
Interventions 2 2 1.000000

Enrollment Metrics

Measure Registries
Min 48.00
1st Qu 295.00
Median 694.50
Mean 5660.25
3rd Qu 2150.00
Max 50000.00

Registry Model

observational_model Study_Count
Cohort 9
Other 2
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 10
Other 2

Follow-up

target_duration Study_Count
1 Year 3
10 Years 2
12 Months 2
5 Years 2
12 Years 1
3 Years 1
6 Months 1